Comfortable

Many years ago, Sherlock was raped and/or tortured. The aggressor(s) kept him blindfolded and earplugged so he couldn't identify them later. Eventually, Sherlock was saved and Mycroft made sure the bad guys got what they deserved.

Years later, an experiment does not go as planned and it renders Sherlock temporarily both blind and deaf. He wakes up in an unfamiliar bed, with unfamiliar hands touching him, he cannot hear nor see anything... he has a panic attack. The only person who can calm him down is John, since Sherlock can recognize him by touch and smell.